Among the methodologies developed to overcome this challenge, in situ polymerization constitutes one of the most viable and promising approaches because. Here we combined a method to align carbon nanotubes with in-situ polymerization of conductive polymer to form composite films and fibers. Polyethylene nanocomposites were obtained by in situ polymerization using both montmorillonite (natural clay) and montmorillonite organically modified with.
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However, drug delivery systems are also developed by in in situ polymerization polymerization. In situ polymerization in the context of drug delivery implies the development of drug delivery systems within the polymerization mixtures.
Despite the numerous polymers available, quite a number of them in situ polymerization not employed for drug delivery because they are not biocompatible and do not possess excellent drug delivery properties.
Hence, there is always the need to synthesize new polymers with improved drug delivery properties tailor-made to achieve specific drug delivery outcomes.
Instead of purchasing preformed polymers for development of drug in situ polymerization, monomers are purchased and novel polymers are formed. One of the benefits of in situ polymerization is that the desired polymer chain length and molecular weight required for a specific drug delivery system can be actualized.
The second benefit is that it can be employed to improve drug loading of particulate and matrix delivery systems.
Furthermore, the desired monomers can be employed in the desired ratio and optimized to achieve certain drug delivery in situ polymerization. In situ polymerization is a method that can be employed to develop in situ polymerization that can withstand the harsh conditions of the gastric region in order to protect and deliver macromolecules through the oral route In situ polymerization such as free radical and interfacial polymerizations are rapid and cross-linking in situ polymerization can be controlled to modulate drug release The polymerization process of photopolymerization for instance can be undertaken at temperatures and pHs within physiological ranges The different in situ polymerization methods that have been used to prepare drug delivery systems include interfacial polymerization 23 — 25free radical polymerization 2627anionic polymerization 28ring-opening polymerization 29frontal polymerization 30micellar copolymerization, and network polymerization This review focuses on highlighting the different techniques of in situ polymerization for oral drug delivery systems with emphasis on drug incorporation during polymerization.
Such drugs include proteins which may be denatured by heat or UV-applied during polymerization.
In Situ Free Radical Solution Polymerization for Films, Microparticles, and Nanospheres Peppas and co-workers prepared complexation polymers which protected proteins such as insulin and calcitonin from possible degradation in the gastric region by the ability of the polymers to respond to changes in pH 32 — Swelling, calcium binding, and enzyme inhibition studies were undertaken However, as the pH increased, the swelling rate increased, as complexation did not occur at higher pHs due in situ polymerization dissociation of complexes.
The complexation hydrogel exhibited good calcium in situ polymerization ability which enabled it to inhibit calcium-dependent enzymes such as trypsin making it a potential carrier for peptides and proteins Peppas and co-workers prepared microparticles of P MAA-g-EG by free in situ polymerization solution polymerization; and insulin and other drugs such as vancomycin and theophyline were incorporated individually by equilibrium partitioning.
Initially, polymer films were obtained which were crushed into microparticles before drug incorporation.
In situ polymerization
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Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems
in situ polymerization December Learn how and when to remove this template message In polymer chemistryin situ polymerization means "in the polymerization mixture.
One example of this method is protein nanogels made by the in situ polymerization method. It has tremendous applications for cancer treatment, vaccination, diagnosis, in situ polymerization medicine, and therapies for loss-of-function genetic diseases.