A concise, bedside resource derived from Harrison's Principles of Internal Medicine, 19th Edition. Perfect for use at the point of care, the Manual presents clinical. Editorial Reviews. About the Author. Dennis Kasper, MD is Professor of Medicine at Harvard. The landmark guide to internal medicine― updated and streamlined for today's students and clinicians. A Doody's Core Title for ! All eChapters in the.


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Since the first edition was published 65 years ago, virtually every area of medicine and medical education has evolved remarkably, and many new fields have emerged.

Many of the updates and changes described here harrisons internal medicine been undertaken with the modern educational and clinical environments harrisons internal medicine mind. This new edition offers a thoroughly updated presentation of the classic pathophysiologic basis of clinical medicine and harrisons internal medicine the cutting-edge methods and tools that are now available for the assessment of symptoms and the effective management of diseases in the modern patient-care environment.

The text is supplemented by germane new photographs, radiographs, illustrations, atlases, patient-care algorithms, tables, and practical demonstrative videos. In the interest of producing the most practical format possible for the 19th edition, a new system of referencing has been used.

The print textbook is available in two volumes. Volume 1 focuses on the foundations of medicine and the understanding and assessment of cardinal disease manifestations; Volume 2 focuses on specific diseases, by system.

This functional division will be helpful to students who are mastering the basis of harrisons internal medicine medicine and to clinicians who are more focused on gaining an harrisons internal medicine understanding of mechanisms and patient care in specific diseases.

Preface/Table of Contents | Harrison's Principles of Internal Medicine

All of these options provide access to our numerous e-chapters as well as to videos and atlases. At that time, peptic ulcer disease was thought to be caused by stress, nearly every tumor that was not resected resulted in death, rheumatic heart disease was widely prevalent, and hepatitis B and HIV infection were unknown.

In the intervening years, both the infectious cause of and the cure for peptic ulcer disease were identified; advances in diagnosis and treatment made it possible to cure two-thirds of cancers; rheumatic heart disease virtually disappeared; atherosclerotic coronary artery disease harrisons internal medicine and harrisons internal medicine least in part through management of modifiable risk factors—began to wane; hepatitis B and its consequences, cirrhosis and hepatocellular carcinoma, became preventable by a vaccine; and HIV, first viewed as a uniformly fatal worldwide scourge, became a treatable chronic disease.

Notably, emerging and reemerging diseases have presented significant challenges to medical research and practice, while a new understanding of systems-wide concepts such as the microbiome offers exciting new possibilities for understanding and managing health and disease in ways never before possible.

Harrison's Principles of Internal Medicine, 20e

The updates cover the latest treatment protocols and address the issue of combination prevention modalities, making the chapter the most up-to-date and comprehensive treatise on HIV disease available. Several other chapters likewise reflect the rapid pace of advancement in the field of immune-related diseases and their treatment.

In addition, a new chapter on IgG4-mediated disease summarizes an important and newly recognized constellation of entities. Readers will find expanded coverage of the neurodegenerative diseases, highlighting advances in their classification and management and delineating the new understanding of mechanisms responsible for the deposition and spread of pathogenic protein aggregates in these disorders.

The chapter on chronic hepatitis discusses in detail the dramatic new discoveries in the use of direct-acting antiviral agents for the treatment of hepatitis C virus disease; these agents are responsible for some of the most exciting therapeutic advances in medicine today. The rapidly expanding application of genetic knowledge to medicine is covered in many chapters, including a new chapter on microbial genomics and infectious diseases and substantially updated chapters on the human microbiome and chromosomal genetic disorders.

Other new chapters address timely topics such as the impact of climate change on harrisons internal medicine, infections in U. Another topic of increasing interest, the impact of aging on health and disease, is addressed by several chapters, including a newly authored chapter on the biology of aging.

New chapters also address diverse topics including the emerging field of tissue engineering, the examination of the comatose patient, the management of heart failure, the major characteristics of helminths and helminthic infections, specific cardiac valvular disorders, venous and lymphatic harrisons internal medicine of the extremities, renovascular disease, late complications of diabetes, chronic myeloid leukemia, heat-related illnesses, fatigue, polyglandular failure syndromes, and nonalcoholic fatty liver harrisons internal medicine and nonalcoholic steatohepatitis.

Supplementing new content and updates on diseases and patient care, new videos in this edition cover sleep disorders, tissue engineering, noninvasive cardiac imaging, examination of the comatose patient, and myasthenia gravis and other diseases of the neuromuscular junction.


New atlases for this edition address noninvasive imaging, percutaneous revascularization, and gastrointestinal endoscopy. We have many people to thank for their efforts in producing this book. First, the authors have done a superb job of producing authoritative chapters that synthesize vast amounts of scientific and clinical data to create state-of-the-art descriptions of harrisons internal medicine disorders encompassed by internal medicine.

Helpful suggestions and critical input have been provided harrisons internal medicine a number of colleagues; particularly notable was the advice of Chung Owyang on the Gastroenterology Section. We are most grateful to our colleagues in each of our editorial offices who have kept track of the work in its various phases harrisons internal medicine facilitated communication with the authors, with the McGraw-Hill Education staff, and among the editors: Patricia Conrad, Patricia L.

The staff at McGraw-Hill Education has been a constant source of support and expertise. Kim Davis, as Associate Managing Editor, has adeptly ensured that the complex production of this multi-authored textbook proceeded smoothly and efficiently.