Alport Syndrome (AS) is a disorder of the glomerular basement membrane, part of the glomerular filtration unit, and is the second highest cause of inherited chronic kidney disease (CKD) after polycystic kidney disease. Alport Syndrome can also cause hearing loss. Alport syndrome is a genetic disorder affecting around 1 in 50, children, characterized by glomerulonephritis, end-stage kidney disease, and hearing loss. Alport syndrome can also affect the eyes, though the changes do not usually affect sight, except when changes to the lens occur in later life.Signs and symptoms · Pathophysiology · Genetics · Diagnosis. Alport syndrome is an inherited disorder of the basement membrane, resulting in progressive renal failure due to glomerulonephropathy, variable sensorineural.